Malignant Hyperthermia: A Management Guide for Perioperative Personnel

This 2-hour CE course is developed for perioperative personnel, including registered nurses, nurse anesthetists, surgical technologists, and anesthesia providers, to enhance clinical preparedness and response to malignant hyperthermia (MH), a rare, life-threatening pharmacogenetic disorder triggered by certain anesthetic agents. The course emphasizes rapid identification, emergency management, and post-crisis care to optimize patient safety in surgical settings.

Participants will review the underlying pathophysiology of MH, including the role of abnormal calcium regulation in skeletal muscle and the genetic mutations most commonly associated with the condition. The course outlines known pharmacologic triggers such as volatile anesthetics and depolarizing muscle relaxants, as well as the early clinical manifestations of MH including hypercapnia, muscle rigidity, tachycardia, and rising body temperature.

Comprehensive guidance is provided on immediate interventions, with a focus on the critical steps of the MH crisis protocol. Emphasis is placed on the timely administration of dantrolene sodium, supportive measures such as active cooling and electrolyte correction, and the organization of the surgical team during the event. The course also covers the proper preparation and stocking of an MH emergency cart, as recommended by the Malignant Hyperthermia Association of the United States (MHAUS).

Post-crisis care, including ICU monitoring, genetic counseling referral, and patient/family education, is also addressed. Realistic case scenarios reinforce learning and highlight the role of effective teamwork and rapid communication in improving patient outcomes during perioperative emergencies.

Learning Objectives:

• Upon successful completion of this course, participants will be able to:
• Understand the pathophysiology and genetic basis of malignant hyperthermia.
• Identify the pharmacologic triggers and early clinical signs of MH.
• Implement emergency protocols, including administration of dantrolene and supportive measures.
• Organize perioperative team roles during an MH crisis.
• Prepare and maintain an MH cart in compliance with safety standards.
• Provide appropriate post-event care and patient education following an MH episode.

Course Completion Requirements:

To complete this CE course and receive full credit, participants must:

• Register for the course.
• Review all course materials.
• Complete the post-test with a passing score of 70% or higher.
• Submit the course evaluation survey.

Note: Some courses may include additional assignments, case reviews, or interactive scenarios.

Important Disclosures:

• Conflict of Interest: The course planners, authors, and presenters have no financial or commercial conflicts of interest related to this educational activity
• Commercial Support: This course has not received sponsorship or financial support from commercial entities.
• Non-Endorsement: Approval of this course as a continuing education activity does not imply endorsement of any products, services, or companies mentioned within the content.
• Off-Label Product Use: No content related to off-label use of FDA-approved products is included in this course.